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Front Immunol 19(13):968639 Liang W, Qi W, Geng Y, Wang L, Zhao J, Zhu K, Wu G, Zhang Z, Pan H, Qian L, Yuan J (2021) Necroptosis activates UPR sensors without disrupting their binding with GRP78

Importantly, the animal models treated with the nanoparticles did not show any signs for pain, stress, or discomfort, and did not lose any weight (Fig

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In the setting of hyperlipidemia, conspicuous reduction in GSH content in the liver was observed, which was accompanied by the reduction in the concentration of cysteine-the rate limiting precursor of GSH, suggesting that reduced availability of cysteine led to impaired GSH production, and subsequent decreased GSH pool size